miRNA调控哺乳动物卵泡发育和卵母细胞成熟的研究进展

doi:10.11843/j.issn.0366-6964.2019.11.001

摘要/Abstract

摘要： 雌性哺乳动物的卵泡发育和卵母细胞成熟受繁殖关键基因的时空调控，miRNA作为一类小的非编码RNA，调节大部分此类基因的表达。近十几年来，研究者通过高通量测序、敲除miRNA生成过程中的关键基因以及过表达或抑制miRNA表达等方法找到了大量与哺乳动物卵泡发育和卵母细胞生长相关的miRNAs。通过研究这些miRNAs及其靶基因的互作关系，最终确定其在哺乳动物卵泡发育和卵母细胞成熟中的作用。本文综述了雌性哺乳动物主要生殖细胞及细胞外miRNAs在卵泡发育和卵母细胞成熟过程中的表达及潜在作用，以期为深入探究雌性哺乳动物繁殖调控机制提供参考。

Abstract: The regulation of female mammalian follicular development and oocyte maturation involves the spatiotemporal regulation of those genes that play key roles in reproduction. miRNAs, as a class of small non-coding RNAs, regulate the expression of most of these genes. Over the last decade, a large number of miRNAs involved in mammalian follicular development and oocyte growth were found through high-throughput sequencing, knockout of key genes involved in miRNA generation, and functional inhibition or overexpression of miRNAs. The function of these miRNAs in mammalian follicular development and oocyte maturation were ultimately determined by studying the interaction with their target genes. The present review focuses on the expression and potential function of major miRNAs during follicular development and oocyte maturation in reproductive cells or extracellular. These results can provide a reference for further exploring the regulation mechanism of mammalian reproduction.

中图分类号:

S814.1

贺小云, 刘秋月, 储明星. miRNA调控哺乳动物卵泡发育和卵母细胞成熟的研究进展[J]. 畜牧兽医学报, 2019, 50(11): 2175-2185.

HE Xiaoyun, LIU Qiuyue, CHU Mingxing. Advances in miRNA Regulating Mammalian Follicular Development and Oocyte Maturation[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2019, 50(11): 2175-2185.

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